Leukocyte antigen CD37 ("CD37") , also known as GP52-40 , tetraspanin-26 (tetraspanin-26) , is a transmembrane protein of the tetraspanin-26 superfamily ^[1,2] , which is the first B is expressed on B cells during the stage of the surrounding mature B cells , but does not exist after the final differentiation into plasma cells. CD37 antigen is only weakly expressed on T cells, bone marrow cells and granulocytes. However, CD37 is also expressed on some malignant B cells, such as cells that cause non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL) ^[3] , indicating that CD37 can be used for B cells Potential therapeutic targets for malignant diseases.

This product targeting CD37 antibodies can be used to overexpress CD37 flow cytometry and detection of the recombinant protein activity of recombinant cell lines.

product name:CD37 single chain antibody

Reactivity: human

Tags: Fc tag

Subclass: human IgG1

Purification method: affinity chromatography

Storage system: PBS, pH 7.4, 20% glycerol

Storage conditions: -20°C refrigerator, avoid repeated freezing and thawing

Illustration: Lane M on the left is: protein MW marker, Lane 1 is: 2ug CD37 single-chain antibody;

The image on the right shows the flow cytometric detection of the binding of CD37 antibody to overexpressing CD37 recombinant cell

Reference materials:

1. A regulatory role for CD37 in T-cell proliferation

2. The tetraspanin superfamily:molecular facilitators

3. High frequency of inactivating tetraspanin CD37 mutations in diffuse large B-cell lymphoma at immune-privileged sites