Full Human Antibody

Full human antibody derived from human primary B cells is constrained by low affinity, limited availability of human samples, sometime ethic problems; humanized mouse strain carrying human germline VDJ region is of great alternative for generation of full human antibody, which devoid of potential immunogenic issues as mouse monoclonal antibody. iCareab now lunch full human antibody development service in combination of humanized mouse and traditional hybridoma technique.

Service Features

Humanized Mice

VDJ region replaced with Human germline counterparts
Omit antibody engineering step
Reliable traditional electrofusion technique
Automatic clone plating and clone pickup

NGS based Hybridoma Sequencing

Traditional hybridoma sequencing and NGS method available to retrieve the full human variable sequences
High through full human antibody preparation

SPF Animal Research Facility

We CARE animal welfare
Humanized mouse housed at their comfortable conditions

In Vivo & In vitro Pharmacodynamic Evaluations

Pre-established cell based assays covering various hot targets
Capability of developing customized assays to exclude unwanted binders
SPF animal facility to serve various in vivo models

Developability Analysis Service Available

Equipped with cutting-edge instrument, many developability evaluation methods are available in our lab, such as thermostability, aggregation analysis, affinity determination and epitope binning, PTM analysis….



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