Protein Stability Analysis

Antibody is structurally and functionally complex molecule. Antibody stability defines the probability of its unfolding or denaturation. Any change in temperature or electrochemical balance may influence its stasis and further leads to destabilization. Misfolded protein can aggregate together. Understanding long term stability of antibody is one of the keys to evaluate the developability of macromolecule drug. Insights into antibody stability will benefit the optimization process of your drugs. Equipped with NanoTemperDSF, we can offer trustworthy, high-resolution stability characterization services to our customer.

As a leading antibody drug research and development cro, iCareAb can provide characterization, validation and stability analysis services for various forms of biopharmaceuticals such as antibodies and proteins. We are equipped with a new generation of nanotemper device PR protein stability analyzer, which is used to analyze and characterize the aggregation, particle formation, thermal stability, etc. of biopharmaceuticals, covering a full range of analysis services from antibody drug clone selection to approval and commercialization.

Service Features

High Throughput Label Free Assay

Minimum manipulation of samples
Detection of intrinsic fluorescence without need of dye staining

Sensitivity and Accuracy

Protein stability under native conditions
Little sample (at ug scale) is required
High quality data generates reliable stability information


Tm:        The unfolding transition temperature, the temperature  at which 50% of the protein is unfolded. 

Tagg:      The temperature at which the protein begins to for aggregates. 

Tonset:    The temperature at which the protein begins to unfold

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