Siglec-15 is a DAP12- related immune receptor, belonging to the immunoglobulin superfamily and the Siglec (sialic acid-binding insulin-like lectin) family. The Siglec family is a cell surface protein that binds sialic acid. They mainly exist on the surface of immune cells and are a subset of type I lectins. Siglec-15 is composed of an immunoglobulin-like domain, a transmembrane domain, and a short cytoplasmic tail. Siglec-15 recognizes sialic acid glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and has a conservative regulatory role in the vertebrate immune system.

This product is a mouse monoclonal antibody targeting Siglec-15 , which can be used for flow cytometric detection of Siglec-15 cell lines or the activity detection of Siglec-15 recombinant protein.

Product name: SIGLEC15 monoclonal antibody

Reactivity: human

Subclass: mouse IgG

Concentration: 1μg/μL

Analysis instrument: flow cytometer

Purification method: affinity chromatography

Storage system: PBS, pH 7.4, 20% glycerol

Storage conditions: -20°C refrigerator, avoid repeated freezing and thawing

Illustration: left lane M is a protein MW marker, Lane 1 is a 10ug SIGLEC15 Antibody; right is detected by flow cytometry CHO-Siglec-15 cell-surface recombinant Siglec-15 expression

Reference materials:

1. Sialic acid binding Ig-like lectin 15 (SIGLEC15)

2. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy