Recombinant human BAFFR protein

【No.】IRP020A 【Protein name】 Recombinant human BAFFR protein
【Gene Sequence Number/Expression Region】Q96RJ3/7-71AA 【Label position】C-terminal Human-Fc Tag
【Restriction sites】Enterokinase 【Packing specification】100μg/tube

BAFF receptor (B-cell activating factor receptor, BAFF-R ), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) or CD268 antigen. The proliferation and metastasis of B lymphoma cells are regulated by the BAFF signaling pathway, and BAFF-R, as a key signal molecule of the BAFF signaling pathway , plays an important role in the proliferation of B  lymphoma cells [1,2] . Studies have shown, of BAFF-R & lt  not expressed in mature B  lymphocytes, and found B  cell lymphoma surface, stimulate B  lymphoma cell proliferation, prevent B the lymphocyte apoptosis plays an important role, is an important research potential related diseases Target point [3-5] . At present, the development of antibody drugs against BAFF-R has entered the third clinical phase.

Product name: Recombinant human BAFFR protein

Species: Human origin

Gene sequence number: Q96RJ3

Tags: Human-Fc Tag

Tag site: C terminal

Restriction site: enterokinase

Expression area: extracellular segment 7-71AA

Host cell:CHO

Purity: >90%

Purification method: Protein A column

Preservation system: PBS+20% glycerol

Storage conditions: -80℃

Picture : Lane M on the left is the protein MW marker, Lane 1 is 15ug BAFFR-Fc protein;

The right picture shows the flow cytometric detection of BAFFR-Fc protein binding to 293T overexpressing  BAFFR- CAR

Reference materials:

1. BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors

2. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells

3. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

4. BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders

5. Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL