Recombinant human IL-13Rα2 protein (IL-13Rα2-entrokinase-FC)

【No.】IRP003A 【Protein name】 Recombinant human IL-13Rα2 protein
【Gene Sequence Number/Expression Region】Q14627/(27-343AA) 【Label position】C-terminal Human-Fc Tag
【Restriction sites】Enterokinase 【Packing specification】100μg/tube

IL-13Rα2 is a glycosylated protein with a molecular weight of approximately 56 kDa . Human IL-13Rα2 includes a signal sequence of 26 amino acids and an intracellular region of 17 amino acids [1] . IL-13Rα2 has been confirmedIt is expressed in mouse spleen, brain and human liver, lung, thymus and other tissues [2-4] . Recent studies have shown thatIL-13Rα2,asa high-affinity receptorfor IL-13 , is highly expressed in malignant gliomas, is related to the poor prognosis of tumors, and can be used as a potential target for the treatment of the disease[5]. This product can be usedFlow cytometric detection of IL-13Rα2 overexpressing cell lines.

Product Name: Recombinant human origin IL-13Rα2 protein

Species: Human origin

Gene sequence number: Q14627

Tags: Human-Fc Tag

Tag site: C terminal

Restriction site: enterokinase

Expression area: extracellular segment ( 27-343AA )

Host cell: CHO-S

Purity: >90%

Purification method: Protein A column

Preservation system: PBS+20% glycerol

Storage conditions: -80℃

Illustration: Lane M on the left is the protein MW marker, Lane 1 is 10ug IL-13Rα2- Fc protein;

The right image shows the flow cytometric detection of IL-13Rα2 protein binding to 293T overexpressing anti- IL-13Rα2 -CAR.

Reference materials:

1. The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway

2. Polymorphisms and ex⁃pression of IL ⁃32:impact on genetic susceptibility andclinical outcome of lung cancer

3. NKP30⁃B7⁃H6interactionaggravates hepatocyte damage through up⁃regulation of in⁃terleukin⁃32expression in hepatitis     B virus⁃related acute⁃on ⁃ chronic liver failure

4. Interleukin⁃32expression in the pancreas

5. IL-13R(alpha)2,a decoy receptor for IL-13 acts as an hinhibitor of IL-4-dependent signal transduction in glioblastoma cells