Siglec-15 is a DAP12- related immune receptor, belonging to the immunoglobulin superfamily and the Siglec (sialic acid-binding insulin-like lectin) family. The Siglec family is a cell surface protein that binds sialic acid. They mainly exist on the surface of immune cells and are a subset of type I lectins. Siglec-15 is composed of an immunoglobulin-like domain, a transmembrane domain, and a short cytoplasmic tail. Siglec-15 recognizes sialic acid glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and has a conservative regulatory role in the vertebrate immune system.
This product is a mouse monoclonal antibody targeting Siglec-15 , which can be used for flow cytometric detection of Siglec-15 cell lines or the activity detection of Siglec-15 recombinant protein.
Product name: SIGLEC15 monoclonal antibody
Subclass: mouse IgG
Analysis instrument: flow cytometer
Purification method: affinity chromatography
Storage system: PBS, pH 7.4, 20% glycerol
Storage conditions: -20°C refrigerator, avoid repeated freezing and thawing
Illustration: left lane M is a protein MW marker, Lane 1 is a 10ug SIGLEC15 Antibody; right is detected by flow cytometry CHO-Siglec-15 cell-surface recombinant Siglec-15 expression
1. Sialic acid binding Ig-like lectin 15 (SIGLEC15)
2. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy