IL-13Rα2 single chain antibody

【No.】IAB009A 【Antibody name】 IL-13Rα2 single chain antibody
【Antibody subtype】human IgG1 【Use】FACS
【Packing specification】100μg/tube 【Mode of transport】-20°C transportation

IL-13Rα2 is a glycosylated protein with a molecular weight of approximately 56 kDa . Human IL-13Rα2 includes a signal sequence of 26 amino acids and an intracellular region of 17 amino acids [1] . IL-13Rα2 has been confirmedIt is expressed in mouse spleen, brain and human liver, lung, thymus and other tissues [2-4] . Recent studies have shown thatIL-13Rα2,asa high-affinity receptorfor IL-13 , is highly expressed in malignant gliomas, is related to the poor prognosis of tumors, and can be used as a potential target for the treatment of the disease[5]. This product can be usedFlow cytometric detection of IL-13Rα2 overexpressing cell lines.

Product name: IL-13Rα2 single chain antibody

Reactivity: human

Tags: Fc tag

Subclass: human IgG1

Purification method: affinity chromatography

Storage system: PBS, pH 7.4, 20% glycerol

Storage conditions: -20°C refrigerator, avoid repeated freezing and thawing

Illustration: Lane M on the left is: protein MW marker, Lane 1 is: 2ug IL-13Rα2 single-chain antibody;

The right picture shows the FACS detection of IL-13Rα2 antibody binding to the recombinant cell line overexpressing IL-13Rα2 .

Reference materials:

1. The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway

2. Polymorphisms and ex⁃pression of IL ⁃32:impact on genetic susceptibility andclinical outcome of lung cancer

3. NKP30⁃B7⁃H6interactionaggravates hepatocyte damage through up⁃regulation of in⁃terleukin⁃32expression in hepatitis     B virus⁃related acute⁃on ⁃ chronic liver failure

4. Interleukin⁃32expression in the pancreas

5. IL-13R(alpha)2,a decoy receptor for IL-13 acts as an hinhibitor of IL-4-dependent signal transduction in glioblastoma cells