EphA2 is a transmembrane tyrosine kinase receptor, a member of the tyrosine kinase receptor (RTKs) superfamily. Like other tyrosine kinases, the EphA2 molecule can be divided into three domains, the extracellular ligand binding domain, the intracellular tyrosine kinase active functional domain and the transmembrane domain. EphA2 is involved in the development of the nervous system and the development of the vascular system. Studies have shown that high expression of EphA2 can be found in breast cancer, colon cancer, prostate cancer, lung cancer, cervical cancer, ovarian cancer and other tissues. It is expected to become a target for the treatment of malignant tumors. And prognostic indicators.
This product can be used for flow cytometric detection of over-expressing EphA2 recombinant cell lines and detection of recombinant protein activity.
Product name: EPHA2 single chain antibody
Tags: Fc tag
Subclass: human IgG1
Purification method: affinity chromatography
Storage system: PBS, pH 7.4, 20% glycerol
Storage conditions: -20°C refrigerator, avoid repeated freezing and thawing
Illustration: Left: Lane M: protein MW marker, Lane 1: 2ug EPHA2 single-chain antibody;
The picture on the right shows the flow cytometric detection of EPHA2 antibody binding to the over-expressing EPHA2 recombinant cell line
1. EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop With Akt
2. EphA2 Is an Essential Mediator of UV Radiation-Induced Apoptosis
3. Activation of EphA2 Kinase Suppresses Integrin Function and Causes Focal-Adhesion-Kinase Dephosphorylation